This paper provides an in-depth analysis of major seaports along the US East Coast, including New York, Boston, Philadelphia, Baltimore, Miami, Savannah, Houston, and New Orleans. It details each port's geographical location, strengths, and suitable applications. The article also clarifies the distinction between intermodal transportation and transshipment. Furthermore, it explores how to leverage intermodal strategies such as sea-land, sea-rail, and sea-air to optimize supply chains, reduce logistics costs, and improve transportation efficiency, offering practical insights for international trade.